For example, the persulfidation level of the neuroprotective ubiquitin E3 ligase, parkin, was reduced in the brains of Parkinson’s disease patients, and treatment with H2S donors (NaSH and GYY4137) enhanced parkin catalytic activity, indicating a neuroprotective role for parkin persulfidation [16]. The gene discussed is PRKN; the disease is Parkinson disease.