The ICF‐associated R823G mutation in DNMT3B is aligned at the same position with the most prevalent acute myeloid leukemia (AML)‐associated mutation R882H in DNMT3A, indicating the importance of this arginine residue in maintaining the MTase activity for both DNMT3A and DNMT3B (Holz‐Schietinger et al., 2012; Ley et al., 2010). This evidence concerns the gene DNMT3B and acute myeloid leukemia.