In keeping with the KO mouse CRC model, we found a considerable fraction of VSTM2A-negative CRC cases with avoidance of spontaneous CD8a+ cell infiltration (Pearson’s chi-squared test p < 0.001, φ = 0.24, Figure 3A), indicating that silencing of VSTM2A in CRC could lead to immunosuppression. Here, CD8A is linked to colorectal carcinoma.