CD8A and neoplasm: In an attempt to quantify the immune cell infiltration into the tumor by IHC staining, we observed significantly less, or the absence of, CD8 signal in the dysplasia, adenocarcinoma tissues, and colon lymph nodes in Vstm2a+/− mice compared with wild-type mice, indicating that reduced Vstm2a could hamper T cell infiltration and immune surveillance (Figures 2B–2D).