ALB and Cirrhosis: For ceftriaxone, the included studies suggest that total CL is increased in patients with cirrhosis when compared with healthy controls (0.78–1.8 versus 0.58 to 1.45 L/h).40 This finding could be explained by the high rate (90%–95%) of protein binding of ceftriaxone; liver cirrhosis leads to impairment of albumin synthesis (the most abundant protein in the human body), which in turn decreases the possibility of ceftriaxone binding to protein.