Mice with PTPN1 inhibition exhibited augmented phosphorylation of INSR and enhanced PI3K/AKT signalling, protecting against diet‐induced obesity, improving whole‐body glucose homoeostasis, decreasing TG and TC and diminishing expression of the lipogenic gene SREBP1.12, 41, 42, 43. Here, AKT1 is linked to obesity due to melanocortin 4 receptor deficiency.