Previous studies have suggested a correlation between EphrinB2, cellular autophagy, and protein kinase C. Sulfaphenazole treatment with cardiac cells could activate cellular autophagy and induce cardioprotective effects by involving EphrinB2 and protein kinase C.28Furthermore, the deletion of the Eph ligand EphinB2 consistently induced autophagy‐mediated cell apoptosis in colon cancer cells.29 Here, EPHA1 is linked to malignant colon neoplasm.