The genetic elimination of Cdc42GAP in mice, termed Cdc42GAP knockout, was found to upregulate Cdc42‐GTP levels in all tissues, contributing to age‐related pathologies such as reduced life expectancy, impaired wound healing, muscle wasting, atherosclerosis, osteoporosis, cancer, diabetes, cardiovascular disorders, and neurodegenerative conditions (Zhu, Xiao, et al., 2023). Here, ARHGAP1 is linked to cardiovascular disorder.