METTL1 is significantly up-regulated in esophageal squamous cell carcinoma, and its mediated tRNA m7 G modification promotes malignant progression of esophageal squamous cell carcinoma through the RPTOR/ULK 1/autophagy axis, and its high expression is associated with poor prognosis of patients [108]. The gene discussed is METTL1; the disease is esophageal squamous cell carcinoma.