The specific mechanism is that METTL14 overexpression triggers an increase in the level of p53 m6 A, while decreasing the mRNA and protein levels of PERP, which is associated with poor prognosis of patients.METTL14 is also a poor prognostic factor in breast cancer.METTL14 overexpression can promote tumor invasion and metastasis through the modification of hsa-miR 146 a-5 p by m6A [161]. The gene discussed is PERP; the disease is breast carcinoma.