Under the regulation of PKB and ribosomal S6 kinase [101], METTL1 can catalyze 7-methylguanosine (m7G) modification in microRNAs and tRNAs, and exerts pro-HCC activity through the PTEN/AKT signaling pathway by inhibiting PTEN signaling. This evidence concerns the gene METTL1 and hepatocellular carcinoma.