METTL1 is highly expressed in enamel cell tumors (AM) and significantly correlated with postoperative recurrence.METTL1 can promote invasive growth of AM through the mitogen-activated protein kinase (MAPK) signaling pathway, and is a poor prognostic factor for AM [107]. The gene discussed is METTL1; the disease is acute myeloblastic leukemia with maturation.