However, another study showed that lactate accumulation in TME mediated K281 and K345 lactoylation in the zinc finger structural domain of METTL3 caused significant upregulation of METTL3 in CRC-infiltrating myeloid cells, which enhanced the immunosuppressive activity of tumor-infiltrating myeloid cells through the lactoylation-METTL3-m6A-JAK/STAT 3 axis and was associated with a poor prognosis in CRC patients. The gene discussed is METTL3; the disease is colorectal carcinoma.