In vitro experiments verified that METTL14 inhibited the proliferation and migration of KIRC cells, while overexpression of METTL14 increased the enrichment of m6A on chromosome 10 Pten, increased Pten mRNA stability in a YTHDF 1-dependent manner, and acted as an anti-tumor effect, which is a good prognostic marker for KIRC [94]. This evidence concerns the gene PTEN and neoplasm.