AKT1 and non-small cell lung carcinoma: The specific mechanism is that METTL3 can m6A-modify the lncRNA ABHD11-AS1 to promote the proliferation of NSCLC cells with the Warburg effect [117]; METTL3 also increases the m6A level of RAC3 mRNA, which increases RAC3 mRNA stability and upregulates the cell migration of CAFs through the AKT/NF-κB pathway promotion [118], all of which are closely associated with poor prognosis of NSCLC patients.METTL3 was significantly upregulated in HCC and correlated with shorter overall survival of HCC patients [119].