METTL1, which is highly expressed in HNSCC, promotes the development and malignancy of HNSCC by up-regulating the translation of overall mRNAs including the PI3K/AKT/mTOR signaling pathway, and has been found to alter the immune landscape, which is associated with the poor prognosis in HNSCC patients [106]. Here, AKT1 is linked to head and neck squamous cell carcinoma.