tRNA N7 methylguanosine (m7G) methyltransferase complex components METTL1 and WD Repeat Domain 4 (WDR 4) expression levels were significantly elevated in human lung cancer samples and negatively correlated with patient prognosis [99].METTL1 and WDR 4 proteins were significantly up-regulated in HCC, which promotes HCC cell proliferation, migration, and invasion, and were negatively correlated with HCC patient survival at levels associated with a poor prognosis for HCC [100]. The gene discussed is METTL1; the disease is lung cancer.