In colorectal cancer, METTL3 promotes the expression of circ1662 by m6A modification of circ1662 through binding to its flanking strand, while circ1662 can regulate SMAD3 expression by accelerating the nuclear localization of YAP1, which ultimately promotes invasive metastasis of colorectal cancer [59]. The gene discussed is SMAD3; the disease is colorectal cancer.