ROC curves showed that METTL3 had a high sensitivity and specificity for the diagnosis of ESCC (the area under the ROC curve was 0.8030, with a sensitivity of 75.00% and a specificity of 72.06%), and at the same time, METTL3 was closely associated with worse prognosis of tumor patients, proving that METTL3 is an important diagnostic marker for ESCC [114, 115]. Here, METTL3 is linked to esophageal squamous cell carcinoma.