METTL16 reduced the m6A methylation level of iron-dead GPX4 mRNA and significantly promoted the degradation of GPX4 mRNA, suggesting that METTL16 enhances the expression level of GPX4 through m6A modification, and thus inhibits iron-death to promote the proliferation of breast cancer cells [62]. The gene discussed is METTL16; the disease is breast carcinoma.