mRNA and protein of METTL3 were found to be high in ESCC, and the level of mRNA expression was correlated with the degree of differentiation and gender of ESCC, and played a METTL3 content showed a positive correlation with the proliferation level of ESCC cells, which may promote ESCC progression by mediating m6 A modification via the p21 axis affecting the cell cycle. The gene discussed is METTL3; the disease is esophageal squamous cell carcinoma.