The assessment of the rate of definition criteria fulfillment during the observation time (total of N = 642 observations) revealed higher median rates of moderate disease activity criterion fulfillment (0.43, IQR 0.54 vs 0.0, IQR 0; p < 0.001), higher rates of raised CRP values criterion fulfillment (0.43, IQR 0.47 vs 0.0, IQR 0; p < 0.001), and higher rates of glucocorticoid criteria fulfillment (0.71, IQR 0.6 vs 0.0, IQR 0.14; p < 0.001) in the pD2T-RA population compared to the eD2T-RA patients (Fig. 4B). This evidence concerns the gene CRP and rheumatoid arthritis.