Multivariate analyses applying logistic regression confirmed that SDAI scores (p < 0.001; OR 1.232, 95% CI 1.085–1.399), CRP values (p = 0.035; OR 2.217, 95% CI 1.059–4.645), use of glucocorticoid (p = 0.004; OR 24.29, 95% CI 2.756–214.085), and use of non-NSAIDS analgesics (p = 0.046; OR 4.502, 95% CI 1.024–19.786) were positively associated with the persistency of the D2T-RA status (Table 3). The gene discussed is CRP; the disease is rheumatoid arthritis.