CASP3 and neoplasm: For example, Aidi injection can regulate the PI3K-AKT signaling pathway, inhibit ERK1/2 protein phosphorylation levels, upregulate Caspase-3, Caspase-9, Fas, Fasl, and Cyt-c expression levels, suppress NF-κB activation, downregulate Bcl-2 protein expression levels, decrease mitochondrial membrane potential, promote tumor cell apoptosis, inhibit DNA synthesis in S-phase tumor cells, arrest tumor cells in the G2/M phase, and hinder their proliferation [9, 10].