There was some disagreement about the potential impact of vosoritide on bone formation, with a range of 1–10 for the statement “Data indicate that mice with achondroplasia showed significantly better new bone formation than wild type mice; there are some concerns over the suppression of FGFR3 signalling by vosoritide during limb lengthening” (LoA 7.20, range 1–10). Here, FGFR3 is linked to achondroplasia.