Numerous inflammation-related cytokines exert their effects through this pathway, including ILs, TNFs, granulocyte–macrophage colony-stimulating factors, and IFN-γ (Morris et al. 2018), the present serological evidence concerning VEXAS syndrome indicates elevated levels of cell factors, notably IL-6 and IFN-γ, which are modulated via the JAK pathway. The gene discussed is IL6; the disease is VEXAS syndrome.