In this cohort of pancreatic cancer there were 18 unique known gain-of-function SVs reported, including FGFR2 F276C (10), FGFR2 C382R (6), FGFR1 N546K (3), FGFR2 Y375C (3), and FGFR2 H167_N173del (2) (Supplementary Fig. 10). Here, FGFR1 is linked to familial pancreatic carcinoma.