On the contrary, IFN-γ release was profoundly significant in case of Exo(PAN34a+DTX) in comparison to the Exo(PANDTX), Exo (PAN-miR 34a) and free DTX which indicated the efficiency of the formulation towards immune stimulation which could trigger the T-cell responses (TCR) to mediate the cancer cell cytotoxicity. The gene discussed is IFNG; the disease is cancer.