EGFR and carcinoma: In 2010, Wong et al. reported a PSA system to encapsulate the imaging molecule, indocyanin green (ICG) in the Polyallylamine (PAH)-phosphate spherical aggregate, which was further coated with anti-EGFR (epidermal growth factor receptor) antibodies to selectively target the EGFR overexpressing malignant tumor in three carcinoma cell lines, 1483 (human head and neck squamous cell), SiHa (human cervical squamous cell), and 435 (cancerous human breast cell) depicting variable expression of EGFR26.