Consistently, pretreatment of BCC cells with NFKB inhibitors JSH23 or withaferin A (WFA), or STAT3 inhibitor ruxolitinib was able to rescue BIT induction by Il1a and Osm (Fig. 6j), demonstrating functional involvements of NFKB1 and STAT3 in BIT induction. The gene discussed is NFKB1; the disease is skin basal cell carcinoma.