Consistently, pretreatment of BCC cells with NFKB inhibitors JSH23 or withaferin A (WFA), or STAT3 inhibitor ruxolitinib was able to rescue BIT induction by Il1a and Osm (Fig. 6j), demonstrating functional involvements of NFKB1 and STAT3 in BIT induction. This evidence concerns the gene IL1A and skin basal cell carcinoma.