As predicted, the top differentially upregulated genes in BCC cells upon 48 h of Il1a and Osm combination treatment included BIT-associated proinflammatory cytokines and cell-cell communication molecules such as acute-phase Saa genes, Chil1, Orm1, Orm2 and Cxcl5 (Fig. 6c). The gene discussed is ORM2; the disease is skin basal cell carcinoma.