GLP-1 can improve abnormalities in glucose metabolism and excessive lipid accumulation by modulating the activity of FOXO1.5,514 Sirt1, a protein deacetylase, plays a key role in delaying cellular aging and regulating metabolism.515–517 GLP-1 may improve the liver’s antioxidant capacity and metabolic function by activating Sirt1, thereby helping to alleviate the pathological changes associated with NASH. This evidence concerns the gene GCG and metabolic dysfunction-associated steatohepatitis.