TGFB1 and Hepatic fibrosis: Interestingly, using previous bulk transcriptomic data from chronic CCl4-treated livers [31], it may be observed that iron appears to accumulate during the progression of liver fibrosis, concomitant with an increase in SASP, TGF-β and fibrotic gene transcriptomic pathways, but all these pathways decreased at longer times, in the tolerance phase (Supplementary Fig. 5B).