TBK1 and cancer: They are involved in a wide range of physiologicalprocesses and are often targets for drug development in treating diseasessuch as cancer and inflammatory disorders.3 Tank-binding kinase 1 (TBK1) is one such enzyme with kinase activity.Encoded by the TBK1 gene in humans, it is a pivotal serine/threoninekinase that orchestrates a variety of critical cellular processes,including innate immunity, inflammation, autophagy, and cell survival/proliferation.4−12