Detailed classification of the different leukemia subtypes has only been possible due to the development of cytochemical staining and immunophenotyping by flow cytometry.1, 5, 6, 7, 24 Both in dogs and people, myelomonocytic leukemia (M4) and monocytic leukemia (M5a, M5b) are the most frequently reported types of AML.6, 14 In addition, specific mutations, epigenetic aberrations, and molecular lesions found to be prognostically and therapeutically relevant have been identified in FLT3, C‐KIT, and RAS oncogenes in canine leukemias, suggesting common oncopathogenic pathways across species.11 This evidence concerns the gene FLT3 and acute myeloid leukemia.