For example, CBD can trigger Noxa (Pmaip1) mediated apoptosis in colorectal cancer cells in a dose dependent manner (0–8 μM) by generating ROS and inducing excessive endoplasmic reticulum (ER) stress, mainly driven by mitochondrial superoxide anion (Jeong et al., 2019). The gene discussed is PMAIP1; the disease is colorectal cancer.