C9orf72 and amyotrophic lateral sclerosis: Moreover, we performed RNA FISH analysis to detect C9orf72 GGGGCC repeat RNA foci, and we found no significant differences for the Cas13d-S24 or Cas13d-S30 groups compared with the Cas13d-NT30 control group (Supplemental Figure 4D), in accordance with the results in C9-ALS iPSCs and iMNs (Supplemental Figure 3, B–D).