ALPK1 and infection: Ryzhakov and colleagues showed that ALPK1 attenuates Th1 responses toHelicobacter hepaticus, by impairing the activation of innate immune cells, suggesting a suppressive role of ALPK1 in hematopoietic cells.22 Moreover, a recent report identifies ALPK1 signaling to be crucial for maintaining intestinal homeostasis after infection with the Gram-negative commensal Akkersmania muciniphila.