Aur at 2 μM and an inhibitor of the Wnt/β-catenin pathway synergistically depressed growth and invasion of human colon cancer cells, growth of subcutaneous xenograft mice models and restrained metastasis in lung metastasis mice models by inhibiting the phosphorylation of STAT3 and inducing caspase-3-dependent apoptosis [69]. This evidence concerns the gene CASP3 and malignant colon neoplasm.