Seven of these clusters were identified in a prior report that evaluated antibody responses among HIV controllers and non-controllers with unknown duration of infection (cluster 1: gag [p17; N-terminus]; cluster 2: gag [p24; C-terminus]; cluster 3: integrase [C-terminus]; cluster 4: vpu [N-terminus]; cluster 5: envelope [gp120; V3 loop and CD4 binding loop]; cluster 6: envelope [gp120/gp41; V5 and fusion peptide]; cluster 7: envelope [gp41; C-terminal heptad repeat region, HR2]) [64]. The gene discussed is CD4; the disease is infection.