TTR and heart failure: Wild-type transthyretin cardiac amyloidosis (ATTRwt-CM) is an under-recognized aetiology of heart failure (HF).1 This type of infiltrative cardiomyopathy results from the extracellular myocardial deposition of misfolded transthyretin proteins, leading to HF, arrhythmias, cardiac conduction abnormalities and thromboembolism.2