While all 4 TCRs are of high avidity and recognize human tumor cells in an HLA-restricted manner, the 3 HLA-A*11:01 restricted TCRs (A11Va, A11Vb, and A11Vc) show some degree of CD8 coreceptor independence, in contrast to the HLA-A*03:01–restricted TCR (A3V), which is strictly dependent on the CD8 coreceptor. This evidence concerns the gene HLA-A and neoplasm.