To investigate the potential effect of systemic inflammation on circulating monocytes of MS patients, we first studied the peripheral blood CD14+ fraction isolated from naive, active relapsing-remitting MS patients and healthy donors (HDs) using spectral flow cytometry and a multiomic approach involving both DNA methylation arrays and bulk RNA sequencing (RNA-Seq) (Figure 1A). Here, CD14 is linked to relapsing-remitting multiple sclerosis.