NFE2L2 and myalgic encephalomeyelitis/chronic fatigue syndrome: When microglia were first treated with LPS and then with CFSs (LPS + CFS), the highest NRF2 level resulted from Lrh19 CFS treatment, although all tested CFSs significantly augmented NFR2 nuclear localization (p < 0.01) relative to untreated and inflamed HMC3 cells.