A select number of proteins were chosen for evaluation in plasma and CSF samples from patients with VWMD (Supplementary file 7), a neurodegenerative disease that is driven by eIF2B mutations and chronic ISR overactivation (van der Knaap et al., 2022), with gene expression and protein levels also being measured in samples from DNL343-treated eIF2B HOM mice. The gene discussed is EIF2B5; the disease is neurodegenerative disease.