Post-infection with Mtb(H37Rv), bacterial loads in the lungs and spleens ofSirt7TG mice were significantly decreasedcompared to those in Sirt7+/+ mice at 4 and 8 weekspost-infection (Fig. 6F and G).Furthermore, enhanced tissue consolidation was observed in the lungs of theSirt7TG mice (Fig.6H), aligning with the hypothesis that SIRT7 actively modulates hostresistance to Mtb infections. This evidence concerns the gene SIRT7 and infection.