To investigate whether increases in IL-4 and IL-5 occurred in LincR-PPP2R5C KO mice infected with C. neoformans, the fungal burden in lung tissue and the levels of IL-4 and IL-5 were detected in WT and LincR-PPP2R5C KO mice at 14 days post infection and 48 h post infection, respectively. This evidence concerns the gene IL4 and infection.