Inaddition, transcriptome analysis further proved that VEGFR2 potentially plays acrucial role in combating EV-A71 infection through the TSAd-Src-PI3K-Akt pathway.The knowledge obtained from this study will provide a scientific basis forunderstanding the function of VEGFR2 in combating EV-A71 infection, aiding thedevelopment of prophylactics and therapeutics against enterovirus infections. Here, SRC is linked to enterovirus infectious disease.