TNFRSF14 and breast cancer: This includes promoting T-cell co-stimulation, activating autoimmune-mediated inflammatory responses, regulating dendritic cell homeostasis, and enhancing host defense against pathogens.[37,38] The mRNA TNFRSF14 expression was downregulated in BC compared with adjacent tumor tissues, which was consistent with previous study.[38] In addition, we also found that TNFRSF14 was associated with T cells, B cells and NK cells.