This suggests that CXCL13 could serve as a valuable diagnostic marker and a potential therapeutic target in BC.[34–36] In our study, CXCL13 was also identified with one of the risk genes which can be predict the diagnosis of BC and we also found the mRNA expression of CXCL13 in BC was higher than that in normal breast tissues. This evidence concerns the gene CXCL13 and breast cancer.