This receptor is found on the surface of various immune cells, including T cells, B cells, and dendritic cells.[37–39] Previous study showed that TNFRSF14 is correlated with a favorable prognosis in various cancer patients, its specific role in BC remains unclear.[38] TNFRSF14 serves as a pivotal role in multiple signaling pathways, including NF-κB, AP-1, AKT, RELA, and others, playing a crucial role in immune system function. The gene discussed is AKT1; the disease is cancer.