CASP1 and breast cancer: Previous study also confirmed that the expression of CASP1 were significant decreased compared with tumor-adjacent tissues(P < .05), and CASP1 may contribute to the enhanced proliferation and invasion of BC cells.[30] Activated by TαPcZn-PDT in MCF-7 cells, CASP1 could promoted apoptosis and pyroptosis.[31] Through survival analysis, we found that high expression of CASP1 was associated with better OS rates.