The results showed CASP8, FADD, CASP6, TAB3, CASP7, PARO1, GSDMD, IRF1, AIM2, ZBP1, RIPK3, TRADD and PYCARD were upregulated in BC samples, whereas NLRP3, TAB2, PSTPIP2, TNFAIP3, MLKL and CASP1 were downregulated in BC compared with normal sample (P < .05) (Fig. 2D). This evidence concerns the gene CASP8 and breast cancer.