After adjusting for confounding factors, the risk of multiple-vessel coronary artery disease increased 2.28 times in the high TyG group.[26] A large number of basic studies have proved that the abnormal conduction of insulin signals in the state of insulin resistance leads to endothelial dysfunction, which leads to vasodilation collapse and cell inflammation, and promotes the deposition of large amounts of low-density lipoprotein cholesterol in the blood vessel wall. The gene discussed is INS; the disease is endothelial dysfunction.