SNRPB and cancer: Small nuclear ribonucleoprotein-associated proteins B (SNRPB), as a core component of the SMN-Sm complex that mediates the assembly of the spliceosome snRNP, as well as a component of the building blocks of the spliceosome, U1, U2, U4, and U5 small nuclear ribonucleoproteins (snRNPs), play a role in pre-mRNA splicing.[24,25] Studies have confirmed that inhibition of SNRP gene expression will lead to disruption of its regulation of downstream genes making cancer cells less viable.[25] SNRPB as a SNRP protein can promote the progression of a variety of cancers.