Furthermore, long-term use of PPIs may also cause secondary hypergastrinemia, which can increase bone resorption through elevated secretion of PTH.[17,18] In summary, the use of PPIs may affect bone health by interfering with calcium absorption and increasing bone resorption, ultimately potentially increasing the risk of osteoporosis and related fractures.[19] In this study, the patient took hydrocortisone tablets 30 mg QD for a long time due to hypopituitarism and took large doses of esomeprazole during hospitalization due to the detection of Helicobacter pylori (+). The gene discussed is PTH; the disease is osteoporosis.