Quercetin, known for its anti-inflammatory, immune-regulating, antioxidant, and cardiovascular protective effects,[13] has been found to activate the PI3K/Akt signaling pathway.[14,15] The docking result of quercetin and RELA has the lowest binding energy of −8.2 kcal/mol, indicating that the combination was quite stable and played a crucial role in regulating PI3K/Akt pathway in the development of hepatic fibrosis. This evidence concerns the gene RELA and Hepatic fibrosis.