HMGB1 and cardiovascular disorder: In cardiovascular diseases, neutrophils aggregate in the vascular lesions, releasing NETs to promote the intravascular thrombosis.[47] In this process, key roles are played by peptidylarginine deiminase (PAD) 4, vWF, platelet TLR4, P-selectin, high mobility group protein 1, neutrophil solute carrier family 44 member 2, and TF.[48]