Eosinophils can release the contents of the particles, causing tissue damage and promoting the progression of inflammation.[51] Adipose tissue eosinophils regulate adipose tissue homeostasis and systemic low-grade inflammation through IL4.[52] In addition, our study also predicted the TFs of hub genes, and these TFs allow us to further explore the regulation of the development of NASH by T2DM. Here, IL4 is linked to type 2 diabetes mellitus.