As effective sensors of changes in the cellular microenvironment, NR4A1 and NR4A2 control metabolism, cardiovascular, and neurological functions and also take into account the homeostasis of immune cells in inflammation and cancer.[40] Sun et al[41] used hyperoside in mice fed with a high-fat diet (HFD) and found that hyperoside regulated macrophage polarization through NR4A1, thereby having a protective effect on HFD-induced NAFLD mice, with significant reductions in steatosis, insulin resistance, and inflammatory response. The gene discussed is NR4A1; the disease is Insulin resistance.