Eosinophils can release the contents of the particles, causing tissue damage and promoting the progression of inflammation.[51] Adipose tissue eosinophils regulate adipose tissue homeostasis and systemic low-grade inflammation through IL4.[52] In addition, our study also predicted the TFs of hub genes, and these TFs allow us to further explore the regulation of the development of NASH by T2DM. This evidence concerns the gene IL4 and metabolic dysfunction-associated steatohepatitis.