MYC and obesity due to melanocortin 4 receptor deficiency: One study reported that intestinal MYC expression followed the same trend as body mass index increase, and specific knockdown of intestinal MYC in mice ameliorated HFD-induced obesity, insulin resistance, and hepatic steatosis and steatohepatitis.[44] The above 8 hub genes are closely related to the process of NASH, which confirms that our results are consistent with those reported in the literature.