Studies have found that GADD45B gene deficiency can accelerate cell senescence and reduce LF.[38] Dong et al[39] found that overexpression of GADD45β by AAV8-mediated gene transfer in a high-fat high-fructose diet-fed mouse model reduced serum and hepatic triglyceride levels and alleviated insulin resistance. The gene discussed is GADD45B; the disease is Insulin resistance.