KEGG enrichment analysis of the key protein modules was performed to draw bubble diagrams of the top 20 pathways with the relevant pathway P values, in which the intersecting targets mainly acted on Pathways in cancer, Kaposi sarcoma-associated herpesvirus infection, PI3K-Akt signaling pathway and AGE-RAGE signaling pathway in diabetic complications, Fluid shear stress and atherosclerosis Proteoglycans in cancer (Fig. 4B). This evidence concerns the gene RENBP and atherosclerosis.