TNF and familial pancreatic carcinoma: Additionally, it can inhibit tumor necrosis factor-a (TNF-a) and the p38/MAPK signaling pathway through the up-regulation of miR-216b, thus having a protective effect on acute pancreatitis.[29] Moreover, quercetin can inhibit the migration activity of pancreatic cancer cells induced by epidermal growth factor.[30] Eupatin also has significant anti-inflammatory and neuroprotective effects.[31]