Furthermore, GPC (18:1/18:2) was demonstrated to be an independent risk factor for lymph node metastasis positively associated with ERRα.[32] In another study, Liu et al reported that GPC is a key metabolite that regulates lipid metabolism and participates in vasculitis.[33] Previous research on 1-oleoyl-2-docosahexaenoyl-GPC was limited to neural regulation in the brain; the role of this metabolite in TAA has yet to be elucidated. The gene discussed is ESRRA; the disease is vasculitis.