Previous studies have suggested that measuring soluble P-selectin levels could serve as a dependable indicator of platelet activation in vivo.[19] A cohort study by Chao et al revealed that platelet activation is an initial response observed in mild or moderate COVID-19, and it is not primarily linked to severe manifestations of the disease.[19,20] Platelets play a crucial role in both coagulation and immune responses, making them valuable biomarkers for identifying potential therapeutic targets related to inflammation or coagulation dysfunction in COVID-19. The gene discussed is SELP; the disease is COVID-19.