STAT3 and cancer: Deficiency of SLC52A1 directly enhances immunosuppressive activity by facilitating STAT3-mediated reactive oxygen species production, contributing to unfavorable prognostic factors in cancer.[15] Among the above genes, ALG3, COL7A1, MST1, and SLC52A1 were upregulated in LUAD and KL was downregulated in LUAD, and all of them were associated with patient prognosis.