Deficiency of SLC52A1 directly enhances immunosuppressive activity by facilitating STAT3-mediated reactive oxygen species production, contributing to unfavorable prognostic factors in cancer.[15] Among the above genes, ALG3, COL7A1, MST1, and SLC52A1 were upregulated in LUAD and KL was downregulated in LUAD, and all of them were associated with patient prognosis. The gene discussed is KL; the disease is cancer.