VPS9D1-AS1 and neoplasm: Based on the fact that the concentration of glutathione (GSH) in tumor cells is approximately 100–1000 times higher than that in the extracellular fluid, GSH can effectively degrade disulfide bonds and release encapsulated siRNA, thereby achieving efficient intracellular siRNA delivery and excellent anticancer effects.[26] Based on the oncogenic role and high level of FAISL expression in TNBC, we use a reducible nanoparticle system for in vivo delivery of siFAISL and evaluate its clinical translational potential in inhibiting the progression and metastasis of TNBC.