Among the validated PTBP1‐affected AS events, we selected DNMT3B, since it is one of the genes whose expression is the most significantly altered upon PTBP1 KD and has a broad effect on tumor progression, especially radioresistance.[20, 21, 22, 23] Consistently, PTBP1 OE led to an obvious increase in DNMT3B‐L inclusion of exon 5 in PCa cells (Figure 4d,e). Here, PTBP1 is linked to posterior cortical atrophy.