PKM and cancer: In addition, PTBP1 could facilitate liver cancer metastasis by activating the exclusion of Axl exon 10 to produce the Axl‐S protein isoform.[26] Meanwhile, PTBP1 could also drive liver cancer glycolysis by activating the inclusion of PKM exon 10 to increase the PKM2 protein isoform.[27] Thus, these data indicate that the differences in the manner of splicing may be mainly responsible for the functional diversity of PTBP1 in cancers.