In addition, PTBP1 could facilitate liver cancer metastasis by activating the exclusion of Axl exon 10 to produce the Axl‐S protein isoform.[26] Meanwhile, PTBP1 could also drive liver cancer glycolysis by activating the inclusion of PKM exon 10 to increase the PKM2 protein isoform.[27] Thus, these data indicate that the differences in the manner of splicing may be mainly responsible for the functional diversity of PTBP1 in cancers. This evidence concerns the gene PTBP1 and liver cancer.