With the assistance of RALY, PTBP1 can bind to the pre‐mRNA of DNMT3B and drive an oncogenic splicing switch in DNMT3B to produce DNMT3B‐L, which in turn induces promoter methylation of DUSP2, thereby increasing resistance of cancer cells to irradiation (Figure 7n). The gene discussed is DUSP2; the disease is cancer.