Indeed, several studies demonstrated that a massive increase in caspase‐1 activity and IL‐1β levels, resulting from an hyperactivation of NLRP3 inflammasome in immune cells infiltrating the white adipose tissue of obese mice, favors the onset and progression of the low‐grade inflammatory condition (also named meta‐inflammation) associated with obesity.17, 38. The gene discussed is NLRP3; the disease is obesity due to melanocortin 4 receptor deficiency.