In support to this view, in our study NLRP3 gene deletion in HFD mice was associated with a comparable weight gain to that of SD‐WT mice as well as a reduction in body weight compared to HFD‐WT animals, thus corroborating the involvement of NLRP3 inflammasome in pathological weight gain associated with obesity.17, 39. This evidence concerns the gene NLRP3 and obesity due to melanocortin 4 receptor deficiency.