Interestingly, HFD‐NLRP3−/− mice showed no increase in the NLRP3 inflammasome‐related inflammatory parameters as well as an absence of enteric gliosis, thus providing evidence, for the first time, of a link among obesity, NLRP3 inflammasome activation and reactive gliosis. The gene discussed is NLRP3; the disease is obesity due to melanocortin 4 receptor deficiency.