NLRP3 and obesity due to melanocortin 4 receptor deficiency: Of interest, HFD‐NLRP3−/− mice were not associated with changes in ZO‐1 and occludin expression, as compared with HFD‐WT mice (Figure 4A,B), indicating that NLRP3−/− mice (characterized by the absence of both NLRP3 inflammasome and mucosal enteric gliotic processes) are less susceptible to the development of mucosal barrier alterations associated with obesity.