In last years, the nucleotide‐binding oligomerization domain leucine rich repeat and pyrin domain containing protein 3 (NLRP3) inflammasome multiprotein complex, expressed in immune/inflammatory cells and EGCs, is emerging as critical player in the pathogenesis of inflammatory responses associated with obesity via the processing and release of interleukin (IL)‐1β and IL‐18.15, 16, 17. Here, NLRP3 is linked to obesity due to melanocortin 4 receptor deficiency.