Preclinical and clinical studies reported an hyperactivation of NLRP3 inflammasome signaling pathway in the presence of obesity, characterized by an increase in caspase‐1 activity and IL‐1β levels, in immune cells infiltrating the adipose tissue, thus corroborating the involvement of NLRP3 inflammasome in the meta‐inflammation associated with obesity.15, 17. The gene discussed is IL1B; the disease is obesity disorder.