Of interest, HFD‐NLRP3−/− mice were not associated with changes in ZO‐1 and occludin expression, as compared with HFD‐WT mice (Figure 4A,B), indicating that NLRP3−/− mice (characterized by the absence of both NLRP3 inflammasome and mucosal enteric gliotic processes) are less susceptible to the development of mucosal barrier alterations associated with obesity. This evidence concerns the gene NLRP3 and Obesity.