In support to this view, in our study NLRP3 gene deletion in HFD mice was associated with a comparable weight gain to that of SD‐WT mice as well as a reduction in body weight compared to HFD‐WT animals, thus corroborating the involvement of NLRP3 inflammasome in pathological weight gain associated with obesity.17, 39. Here, NLRP3 is linked to obesity disorder.