By contrast, HFD‐NLRP3−/− mice (characterized by the absence of both NLRP3 inflammasome activation and mucosal enteric gliotic processes) are less susceptible to the development of mucosal barrier alterations associated with obesity, thus highlighting once again a link among HFD intake, NLRP3 inflammasome activation, enteric gliotic processes and intestinal mucosal barrier alterations. This evidence concerns the gene NLRP3 and Obesity.