In addition, HFD‐NLRP3−/− mice displayed a reduction in active caspase‐1 expression as well as in circulating and colonic IL‐1β levels, thus confirming previous evidence describing the involvement of NLRP3 inflammasome in the pathophysiology of obesity and related inflammation.17, 38. Here, IL1B is linked to obesity due to melanocortin 4 receptor deficiency.