In order to confirm the interplay among obesity, NLRP3 inflammasome activation and enteric gliosis, we performed a double‐staining immunofluorescence analysis to investigate ASC specks, reflecting an active status of the inflammasome,47, 48 at level of mucosal and neuromuscular GFAP‐positive glial cells. This evidence concerns the gene NLRP3 and obesity due to melanocortin 4 receptor deficiency.