90 The abundance of C.albicans is increased in the gut of IBD patients compared to healthy controls.97 In its hyphal form, C.albicans upregulates the endothelial converting enzyme 1 (ECE1) gene, leading to greater abundance of the ECE1 protein.98 This protein undergoes proteolytic processing to release its active form, known as Candidalysin. This evidence concerns the gene ECE1 and inflammatory bowel disease.