A broader interaction analysis performed by Mukherjee et al. identified major populations with strong incoming receptor signals within the lamina propria of CD strictures, including myeloid cells (CXCL9/CXCL10hi, inflammatory monocytes, NLRP3hi, and Met-allothioneinhi), T/NK cells, endothelial cells, MMP/WNT5A+ fibroblasts, and pericytes (10). Here, WNT5A is linked to Cowden disease.