To translate our findings to human disease, we next analyzed ADAMTS12 expression in recently published human kidney scRNA-Seq data on PDGFRβ+ cells (mesenchyme enriched, n = 8), CD10– cells (proximal tubule depleted, n = 15), and a large kidney dataset of AKI and chronic kidney disease (CKD) (Kidney Precision Medicine Project KPMP], n = 47) (2, 11). Here, MME is linked to acute kidney injury.