ADAMTS12 and acute kidney injury: To confirm mesenchyme-restricted Adamts12 expression, we next analyzed a publicly available single-nucleus RNA-Sequencing (snRNA-Seq) time course of murine IRI and detected fibroblast- and pericyte-specific Adamts12 expression, with the strongest upregulation by fibroblasts on day 2 after acute kidney injury (AKI) (Supplemental Figure 1, K and L) (10).