SOAT1 and essential thrombocythemia: Prior studies have well established the cytolytic effect of autoreactive T cells on hair follicles in AA.1, 2, 3, 4 Additionally, studies have shown increased serum inflammatory cytokines in patients with ET, enhanced T helper 17 cell development with STAT3 activation, and chronic activation of antigen-presenting cells in the context of JAK-STAT signaling.1